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Hypersecretion of GH causes acromegaly, and strategies that block the release of GH or that inhibit GH receptor (GHR) activation are the primary forms of medical therapy for this disease. During puberty, increased GH levels impair glucose tolerance and induce insulin resistance. Substantially since the entrance of this product in the early 2000s on the black market. This period, the estrogen level is high compared to the testosterone level.
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